What is FLEXISEQ®?

FLEXISEQ is a gel containing nanostructures called Sequessome™ vesicles, which are able to cross the skin and target sites of pain.

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  FLEXISEQ is a pain relieving gel
  FLEXISEQ is a topically applied gel. FLEXISEQ is specially formulated to combat joint pain associated with osteoarthritis. Daily application in the morning and evening is enough to start to bring about real improvement in joint pain in as little as two days.

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  FLEXISEQ ingredients have an excellent safety profile
  FLEXISEQ does not contain any pharmaceutical drug, and consequently FLEXISEQ benefits from an excellent safety profile avoiding the documented risks that may be associated with many common pain medicines.

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  FLEXISEQ is clinically proven
  FLEXISEQ is clinically proven to greatly reduce pain and restore joint function (mobility). FLEXISEQ was shown to be as effective as a leading oral prescription-only medicine in trials with hundreds of patients

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  FLEXISEQ is not a pharmaceutical
  FLEXISEQ is registered as a medical device. FLEXISEQ does not contain any pharmaceutically active ingredients and this means it doesn't contain any drugs that might interact with medication you may be taking for your pain or any other ailment.

Sequessome Technology

  Effective Bio-lubricants

FLEXISEQ™ is an aqueous gel packed with microscopic spheres called Sequessome™ vesicles. These spheres are made of molecules called phospholipids which naturally occur in the body and variants of which contribute to the lubricating properties of synovial fluid.

In addition, Sequessome™ vesicles are highly flexible and compressible which increases their lubricating ability.

Sequessome Technology

Journey to the Joint

After FLEXISEQ™ is applied to the skin, the water-based gel begins to dry which triggers the activity of the Sequessome™ vesicles contained within.

A Sequessome™ loves to be surrounded by water and as the water in its surrounding gel evaporates, it seeks out the next closest source of water – below the skin. The super-flexibility of the micro-spheres allows them to squeeze easily between skin cells and travel gently along the natural spaces found between them.

A layer of FLEXISEQ gel contains millions of Sequessome™ vesicles and this great volume of spheres entering the skin drives those already inside even deeper. Subsequently, Sequessome™ vesicles continue travelling to beyond the skin, through underlying tissues and into joints where they populate the watery environment of the synovial fluid.

Sequessome Technology

Osteoarthritic Joint

The Sequessome™ vesicles contained within the joint capsule are attracted to the cartilage and accumulate on the damaged cartilage surfaces creating a “film” of lubricating phospholipids.

Through this action, Sequessome™ vesicles replenish the depleted layer of lubricants otherwise found on healthy cartilage, resulting in proven pain relief and reduction of joint stiffness. Longer term, further deterioration of the cartilage may be slowed.

Benefits of using FLEXISEQ

• Proven pain relief and restoration of joint function.
• Excellent safety profile. The only product related side effects experienced in large trials were minor, transient skin irritations.

• FLEXISEQ is a convenient topical gel.
• No known interactions with drugs and has been used in conjunction with other medications prescribed for the pain associated with osteoarthritis.

Safety

• To date, no serious side effects have been reported that are related to the use of FLEXISEQ.
• In around 1000 patients, roughly one in ten experienced some minor skin irritations most of which disappeared after a few weeks of continued use.